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In vitro s tudies in human liver and intestinal microsomes indicated that clindamycin is predominantly metabolized by cytochrome p450 3a4 cyp3a4 , with minor contribution from cyp3a5, to form clindamycin sulfoxide and a minor metabolite, n-desmethylclindamycin.

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clindamycin is rarely the drug of choice for either gram-positive or anaerobic infections, with the exceptions of severe streptococcal cellulitis fasciitis, diabetic foot and anaerobic lung infections.

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clindamycin works by preventing bacteria from producing proteins that are essential to them.

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